Brock Purdy, George Kittle & 3 More 49ers Plays to Target vs. Seahawks
The NFC West Title Showdown: Key Plays for PrizePicks Users
The Seattle Seahawks are set to face the San Francisco 49ers on Saturday night, marking the final game of Week 18. This high-stakes matchup is crucial for both teams as they battle for the NFC West title and a shot at the conference’s No. 1 seed. With such significant implications, there are several compelling PrizePicks plays that could offer valuable opportunities for bettors. Here are five top plays to consider:
Christian McCaffrey Over 68.5 Rushing Yards

Christian McCaffrey has been a standout performer this season, leading the 49ers in both rushing and receiving. In his last two games, he has accumulated 257 yards on 44 carries, showcasing his role as a primary ball carrier. While facing a strong Seattle run defense, the 68.5-yard line presents a favorable opportunity. Given his consistent performance and volume, it’s reasonable to expect McCaffrey to exceed this mark.
George Kittle Over 63.5 Receiving Yards

Despite an injury to Ricky Pearsall, George Kittle is expected to play, continuing his impressive streak of production. Kittle has consistently surpassed 64 yards in each of his last six games, averaging over 80 receiving yards during that span. As the 49ers’ top receiving option, he is well-positioned to build on his recent success and finish the regular season strongly.
Brock Purdy Over 244.5 Passing Yards

Brock Purdy has delivered some of the best quarterback performances in the NFL over the past three games. He has thrown for at least 295 yards in each of those contests, accumulating 13 touchdowns. Although the Seahawks have a solid pass defense, the 49ers’ passing attack should provide enough volume for Purdy to surpass his 244.5-yard line.
Sam Darnold Over 241.5 Passing Yards

Sam Darnold has maintained strong performance in the passing game despite some turnovers. Ranked fifth in the league in passing yards, he has completed 67.2% of his passes for 3,850 yards and 25 touchdowns. San Francisco’s weak pass defense, ranked No. 25 in the NFL, allows for 250 passing yards in their last two games. This trend suggests that Darnold could easily exceed the 241.5-yard mark.
Jaxon Smith-Njigba Over 95.5 Receiving Yards

Jaxon Smith-Njigba has emerged as one of the top wide receivers in the league, leading the NFL in receiving yardage. Through 16 games, he has recorded 1,709 yards and 10 touchdowns, averaging 106.8 yards per game. Facing a weaker secondary, Smith-Njigba is poised for another strong performance to close out the season.
For more insights into Week 18 fantasy football matchups and underdog props, check out additional resources. Stay tuned for more updates and analysis on key players and strategies for the upcoming games.